Q1: Describe the specific meaning of the NNT value you have just calculated (maximum of 5 words).
Q2: Ipilimumab is a new targeted therapy for metastatic melanoma and is also being considered for addition to Robert’s hospital’s formulary. It has been estimated that the incremental cost-effectiveness of ipilimumab is $100,000 per QALY. If there is only enough funding to add either prasugrel or ipilimumab to the formulary, which would you choose solely on the basis of cost-effectiveness? Explain your reasoning (maximum of 100 words).
Q3: Adrenoceptor agonists may be used in the pre-hospital setting for the treatment of a number of cardiovascular and respiratory conditions including cardiac arrest and acute asthma.
Question: Concisely explain how the receptor selectivity of adrenoceptor agonists impacts on the therapeutic efficacy of these drugs and contributes to the potential for adverse effects caused by these drugs (maximum of 200 words).
Q4: A novel allosteric modulator that activates the enzyme phosphodiesterase-5 is currently under development as a pre-hospital treatment for severe acute hypotension.
Question: Discuss the theoretical molecular interactions and clinical consequences that would result from co-administering this drug to an individual currently being treated in the community with an organic nitrate such as isosorbide mononitrate and hypothesis a pre-hospital indication where it would be appropriate to administer the new drug to an individual being treated with isosorbide mononitrate. (maximum 150 words)
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